Blar i forfatter "Morelli, Vania Maris"

Viser treff 1-20 av 30

    • Chronic obstructive pulmonary Disease and risk of mortality in patients with venous thromboembolism - the Tromsø Study 

      Børvik, Trond; Brækkan, Sigrid Kufaas; Evensen, Line; Brodin, Ellen Elisabeth; Morelli, Vania Maris; Melbye, Hasse; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-30)
      <i>Background</i> - Previous studies have shown increased mortality in venous thromboembolism (VTE) patients with chronic obstructive pulmonary disease (COPD), but it is unknown to what extent the association is influenced by the severity of COPD and physical inactivity.<p> <p><i>Objectives</i> - This article investigates whether COPD, and stages of COPD, influenced the risk of mortality after a ...

    • Combined effect of high factor VIII levels and high mean platelet volume on the risk of future incident venous thromboembolism 

      Hansen, Ellen-Sofie; Edvardsen, Magnus; Aukrust, Pål; Ueland, Thor; Hansen, John Bjarne; Brækkan, Sigrid Kufaas; Morelli, Vania Maris (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-29)
      Background - High factor VIII (FVIII) levels and large platelets, as reflected by a high mean platelet volume (MPV), are separately associated with increased risk of venous thromboembolism (VTE). Whether the combination of high FVIII levels and large platelets has a supra-additive effect on VTE risk is unknown.<p> <p>Objectives - We aimed to investigate the joint effect of high FVIII levels and ...

    • Combined effects of plasma von Willebrand factor and platelet measures on the risk of incident venous thromboembolism 

      Edvardsen, Magnus; Hansen, Ellen-Sofie; Hindberg, Kristian; Morelli, Vania Maris; Ueland, Thor; Aukrust, Pål; Brækkan, Sigrid Kufaas; Holtet Evensen, Line; Hansen, John Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-23)
      Plasma von Willebrand factor (VWF) and platelet reactivity are risk factors for venous thromboembolism (VTE), and VWF can promote hemostasis by interaction with platelets. In this study, we explored the combined effects of plasma VWF and platelet measures on the risk of incident VTE. A population-based nested case-control study with 403 cases and 816 controls was derived from the Tromsø Study. VWF, ...

    • Cross-Ancestry Investigation of Venous Thromboembolism Genomic Predictors 

      Thibord, Florian; Klarin, Derek; Brody, Jennifer A.; Chen, Ming-Huei; Levin, Michael G.; Chasman, Daniel I.; Goode, Ellen L.; Hveem, Kristian; Teder-Laving, Maris; Martinez-Perez, Angel; Aïssi, Dylan; Daian-Bacq, Delphine; Ito, Kaoru; Natarajan, Pradeep; Lutsey, Pamela L.; Nadkarni, Girish N.; de Vries, Paul S.; Cuellar-Partida, Gabriel; Wolford, Brooke N.; Pattee, Jack W.; Kooperberg, Charles; Brækkan, Sigrid Kufaas; Li-Gao, Ruifang; Saut, Noemie; Sept, Corriene; Germain, Marine; Judy, Renae L.; Wiggins, Kerri L.; Ko, Darae; O'Donnell, Christopher J.; Taylor, Kent D.; Giulianini, Franco; De Andrade, Mariza; Nøst, Therese Haugdahl; Boland, Anne; Empana, Jean-Philippe; Koyama, Satoshi; Gilliland, Thomas; Do, Ron; Huffman, Jennifer E.; Wang, Xin; Zhou, Wei; Manuel Soria, Jose; Carlos Souto, Juan; Pankratz, Nathan; Haessler, Jeffery; Hindberg, Kristian Dalsbø; Rosendaal, Frits R; Turman, Constance; Olaso, Robert; Kember, Rachel L.; Bartz, Traci M.; Lynch, Julie A.; Heckbert, Susan R.; Armasu, Sebastian M.; Brumpton, Ben Michael; Smadja, David M.; Jouven, Xavier; Komuro, Issei; Clapham, Katharine R.; Loos, Ruth J F; Willer, Cristen J.; Sabater-Lleal, Maria; Pankow, James S.; Reiner, Alexander P.; Morelli, Vania Maris; Ridker, Paul M.; Vlieg, Astrid van Hylckama; Deleuze, Jean-François; Kraft, Peter; Rader, Daniel J.; Psaty, Bruce M.; Skogholt, Anne Heidi; Emmerich, Joseph; Suchon, Pierre; Rich, Stephen S.; Vy, Ha My T; Tang, Weihong; Jackson, Rebecca D.; Hansen, John Bjarne; Morange, Pierre-Emmanuel; Kabrhel, Christopher; Trégouët, David-Alexandre; Damrauer, Scott M.; Johnson, Andrew D.; Smith, Nicholas L. (Journal article; Tidsskriftartikkel, 2022)
      <p><i>Background:</i> Venous thromboembolism (VTE) is a life-threatening vascular event with environmental and genetic determinants. Recent VTE genome-wide association studies (GWAS) meta-analyses involved nearly 30 000 VTE cases and identified up to 40 genetic loci associated with VTE risk, including loci not previously suspected to play a role in hemostasis. The aim of our research was to expand ...

    • D-Dimer Measured at Diagnosis of Venous Thromboembolism is Associated with Risk of Major Bleeding 

      Johnsen, Håkon Sandbukt; Hindberg, Kristian; Bjøri, Esben; Brodin, Ellen Elisabeth; Brækkan, Sigrid Kufaas; Morelli, Vania Maris; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-25)
      Identification of patients at risk of major bleeding is pivotal for optimal management of anticoagulant therapy in venous thromboembolism (VTE). Studies have suggested that D-dimer may predict major bleeding during anticoagulation; however, this is scarcely investigated in VTE patients. We aimed to investigate the role of D-dimer, measured at VTE diagnosis, as a predictive biomarker of major bleeding. ...

    • Diagnostic Blood Biomarkers for Acute Pulmonary Embolism: A Systematic Review 

      Wikan, Vårin Eiriksdatter; Tøndel, Birgitte Gladsø; Morelli, Vania Maris; Brodin, Ellen Elisabeth; Brækkan, Sigrid Kufaas; Hansen, John Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-06)
      (1) Background: The current diagnostic algorithm for acute pulmonary embolism (PE) is associated with the overuse of CT pulmonary angiography (CTPA). An additional highly specific blood test could potentially lower the proportion of patients with suspected PE that require CTPA. The aim was to summarize the literature on the diagnostic performance of biomarkers of patients admitted to an emergency ...

    • Elevated plasma D-dimer levels are associated with risk of future incident venous thromboembolism 

      Hansen, Ellen-Sofie; Rinde, Fridtjof Balteskard; Edvardsen, Magnus; Hindberg, Kristian; Latysheva, Nadezhda; Aukrust, Pål; Ueland, Thor; Michelsen, Annika Elisabet; Hansen, John Bjarne; Brækkan, Sigrid Kufaas; Morelli, Vania Maris (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-25)
      <p><i>Background</i> D-dimer, a global biomarker for activation of the coagulation and fibrinolysis systems, is useful in assessing individual risk of venous thromboembolism (VTE) recurrence. However, there is limited information on the association between D-dimer and risk of a first lifetime VTE event. <p><i>Objectives</i> To investigate the association between plasma D-dimer levels and risk of ...

    • Elevated plasma levels of plasminogen activator inhibitor-1 are associated with risk of future incident venous thromboembolism 

      Frischmuth, Tobias; Hindberg, Kristian; Aukrust, Pål; Ueland, Thor; Brækkan, Sigrid Kufaas; Hansen, John Bjarne; Morelli, Vania Maris (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-15)
      Background: Plasminogen activator inhibitor-1 (PAI-1), the main inhibitor of fibrinolysis, is frequently elevated in obesity and could potentially mediate the risk of venous thromboembolism (VTE) in obese subjects. However, whether PAI-1 is associated with VTE remains uncertain.<p> <p>Objective: To investigate the association between plasma PAI-1 levels and risk of future incident VTE and whether ...

    • Hand grip strength and risk of incident venous thromboembolism: The Tromsø study 

      Leknessund, Oda; Morelli, Vania Maris; Strand, Bjørn Heine; Hansen, John Bjarne; Brækkan, Sigrid Kufaas (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-04)
      <p><b> Background</b> Hand grip strength (HGS), a common proxy of whole-body muscular strength, is associated with a wide range of adverse health outcomes and mortality. However, there are limited data on the association between HGS and risk of venous thromboembolism (VTE). <p><b> Objectives</b> We aimed to investigate the association between HGS and risk of incident VTE in a population-based ...

    • Hand grip strength in venous thromboembolism: risk of recurrence and mortality 

      Leknessund, Oda; Morelli, Vania Maris; Hansen, John Bjarne; Brækkan, Sigrid Kufaas (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-29)
      Background - There is limited information on the relationship between muscle strength and recurrence and mortality after incident venous thromboembolism (VTE).<p> <p>Objectives - To investigate whether weak hand grip strength (HGS) was associated with risk of recurrence and mortality in patients with VTE recruited from the general population.<p> <p>Methods - Participants from the Tromsø Study ...

    • High Levels of Complement Activating Enzyme MASP-2 Are Associated With the Risk of Future Incident Venous Thromboembolism 

      Damoah, Christabel Esi; Snir, Omri; Hindberg, Kristian Dalsbø; Garred, Peter; Ludviksen, Judith K; Brækkan, Sigrid Kufaas; Morelli, Vania Maris; Mollnes, Tom Eirik; Hansen, John Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-21)
      Background: Experimental studies have shown that the complement activating enzyme MASP-2 (mannose-binding lectin associated serine protease 2) exhibits a thrombin-like activity and that inhibition of MASP-2 protects against thrombosis. In this study, we investigated whether plasma MASP-2 levels were associated with risk of future venous thromboembolism (VTE) and whether genetic variants linked to ...

    • High plasma levels of C1-inhibitor are associated with lower risk of future venous thromboembolism 

      Grover, Steven P.; Snir, Omri; Hindberg, Kristian Dalsbø; Englebert, Tatianna M.; Brækkan, Sigrid Kufaas; Morelli, Vania Maris; Jensen, Søren Beck; Wolberg, Alisa S.; Mollnes, Tom Eirik; Ueland, Thor; Mackman, Nigel; Hansen, John Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-31)
      Background - C1-inhibitor (C1INH) is a broad-acting serine protease inhibitor with anticoagulant activity. The impact of C1INH plasma levels within the normal physiological range on risk of venous thromboembolism (VTE) is unknown. We assessed the association of plasma C1INH levels and VTE risk and evaluated the impact of C1INH on thrombin and plasmin generation in ex vivo assays.<p> <p>Methods - ...

    • Impact of prothrombotic genotypes on the association between family history of myocardial infarction and venous thromboembolism 

      Småbrekke, Birgit; Balteskard Rinde, Ludvig; Evensen, Line Holtet; Morelli, Vania Maris; Hveem, Kristian; Gabrielsen, Maiken Elvestad; Njølstad, Inger; Mathiesen, Ellisiv B.; Rosendaal, Frits Richard; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-24)
      <i>Background</i>: Family history of myocardial infarction (FHMI) is known to increase the risk of venous thromboembolism (VTE).<p> <p><i>Objectives</i>: To investigate the effect of prothrombotic genotypes on the association between FHMI and VTE in a case‐cohort recruited from a general population.<p> <p><i>Methods</i>: Cases with a first VTE (<i>n</i> = 1493) and a subcohort (<i>n</i> = ...

    • Impact of respiratory symptoms and oxygen saturation on the risk of incident venous thromboembolism-the Tromsø study. 

      Børvik, Trond; Evensen, Line; Morelli, Vania Maris; Melbye, Hasse; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-09)
      Background: Chronic obstructive pulmonary disease (COPD) is associated with risk of venous thromboembolism (VTE). It remains unknown whether individual respiratory symptoms and lowered oxygen saturation (SpO<sub>2</sub>), individually and in combination with COPD, affect the risk of VTE.<p> <p> Objectives: To investigate whether measures of respiratory impairments including respiratory symptoms ...

    • Impact of the von Willebrand factor-ADAMTS-13 axis on the risk of future venous thromboembolism 

      Edvardsen, Magnus; Hansen, Ellen-Sofie; Ueland, Thor; Aukrust, Pål; Brækkan, Sigrid Kufaas; Morelli, Vania Maris; Hansen, John Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-01)
      Background - von Willebrand factor (VWF) and its cleaving protease, ADAMTS-13, form a pivotal axis that regulates hemostasis. However, the role of the VWF-ADAMTS-13 axis in the risk of future venous thromboembolism (VTE) is unknown.<p> <p>Objectives - To investigate whether plasma ADAMTS-13 levels and an imbalance with VWF levels, assessed as the VWF/ADAMTS-13 ratio, are associated with the risk ...

    • Joint Effect of Multiple Prothrombotic Genotypes and Mean Platelet Volume on the Risk of Incident Venous Thromboembolism 

      Jakobsen, Lisa; Frischmuth, Tobias; Brækkan, Sigrid Kufaas; Hansen, John Bjarne; Morelli, Vania Maris (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-31)
      Background - A high mean platelet volume (MPV), a marker of increased platelet reactivity, is a risk factor for venous thromboembolism (VTE). Whether established prothrombotic single nucleotide polymorphisms (SNPs) further increase the VTE risk in subjects with high MPV because of biological interaction remains unknown.<p> <p>Aim - To investigate the joint effect of high MPV and prothrombotic ...

    • Joint Effect of Multiple Prothrombotic Genotypes and Obesity on the Risk of Incident Venous Thromboembolism 

      Frischmuth, Tobias; Hindberg, Kristian; Gabrielsen, Maiken Elvestad; Brumpton, Ben Michael; Hveem, Kristian; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne; Morelli, Vania Maris (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-05-03)
      <p><b>Background</b> The impact of the combination of obesity and multiple prothrombotic genotypes on venous thromboembolism (VTE) risk remains unclear. <p><b>Objective</b> To investigate the joint effect of obesity and a genetic risk score (GRS) composed of established prothrombotic single nucleotide polymorphisms (SNPs) on VTE risk using a population-based case–cohort. <p><b>Methods</b> Cases ...

    • Joint effect of myocardial infarction and obesity on the risk of venous thromboembolism: The Tromsø Study 

      Sejrup, Joakim Knutsen; Tøndel, Birgitte Gladsø; Morelli, Vania Maris; Løchen, Maja-Lisa; Njølstad, Inger; Mathiesen, Ellisiv B.; Wilsgaard, Tom; Hansen, John Bjarne; Brækkan, Sigrid Kufaas (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-19)
      Background: Myocardial infarction (MI) is associated with an increased risk of venous thromboembolism (VTE). Obesity is a recognized risk factor for both MI and VTE. Whether obesity further increases the risk of VTE in MI patients is scarcely investigated.<p> <p>Aim: To study the joint effect of MI and obesity on the risk of VTE. <p>Methods: Study participants (n = 29 410) were recruited from ...

    • Myocardial infarction as a transient risk factor for incident venous thromboembolism: Results from a population-based case-crossover study 

      Sejrup, Joakim Knutsen; Børvik, Trond; Grimnes, Gro; Isaksen, Trond; Hindberg, Kristian; Hansen, John-Bjarne; Morelli, Vania Maris; Brækkan, Sigrid Kufaas (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-16)
      Patients with myocardial infarction (MI) are at increased short-term risk of venous thromboembolism (VTE). The mechanisms behind this association are unclear. We aimed to investigate the impact of acute MI as a transient risk factor for incident VTE while taking other concomitant VTE risk factors into account. We conducted a case–crossover study of VTE patients (<i>n</i> = 707) recruited from the ...

    • Myocardial infarction, prothrombotic genotypes, and venous thrombosis risk: The Tromsø Study 

      Sejrup, Joakim Knutsen; Morelli, Vania Maris; Løchen, Maja-Lisa; Njølstad, Inger; Mathiesen, Ellisiv B.; Wilsgaard, Tom; Hansen, John-Bjarne; Brækkan, Sigrid Kufaas (Journal article; Tidsskriftartikkel; Peer reviewed; Master thesis; Mastergradsoppgave, 2020-01-27)
      <p><i>Background - </i>The risk of venous thromboembolism (VTE) is increased after a myocardial infarction (MI). Some prothrombotic genotypes associated with VTE have also been associated with risk of MI. Whether prothrombotic single‐nucleotide polymorphisms (SNPs) further increase the risk of VTE in MI patients is scarcely investigated. <p><i>Aim - </i>To study the combined effect of MI and ...